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Interactions médicamenteuses

Cefixime + Typhoid vaccine live

Gravité: Majeure

Cefixime and Typhoid vaccine live: major interaction.

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Résumé

Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi replicating in the gut. Cefixime is used to treat typhoid and may reduce vaccine viability and the immune response.

Ce que signifie cette interaction, en termes simples

Cefixime and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Niveau de preuve: Moderate

Pourquoi elle survient

Antibacterial activity inhibits the live attenuated Salmonella strain, reducing immunogenicity.

Conduite à tenir

Give live oral typhoid vaccine at least 3 days after the last cefixime dose, or vaccinate beforehand. Use the inactivated parenteral vaccine if timing cannot be separated.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cefixime with Typhoid vaccine live?

MediHelp rates the interaction as major. Cefixime and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oral live typhoid vaccine depends on viable attenuated Salmonella Typhi replicating in the gut. Cefixime is used to treat typhoid and may reduce vaccine viability and the immune response.

How serious is the interaction between Cefixime and Typhoid vaccine live?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give live oral typhoid vaccine at least 3 days after the last cefixime dose, or vaccinate beforehand. Use the inactivated parenteral vaccine if timing cannot be separated.

What other medicines interact with Cefixime?

MediHelp also lists interactions of Cefixime with, for example, Cholera vaccine, Kanamycin, Microbiota. The full list is on the Cefixime page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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