Interactions médicamenteuses
Cefixime + Kanamycin
Gravité: Modérée
Cefixime and Kanamycin: moderate interaction.
Dernière mise à jour
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Résumé
Aminoglycosides such as kanamycin are nephrotoxic and ototoxic, and cephalosporins have occasionally been associated with additive renal injury when given alongside them. Cefixime is itself rarely nephrotoxic and is renally cleared, so reduced renal function may raise exposure to both drugs.
Ce que signifie cette interaction, en termes simples
Cefixime and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Possible additive nephrotoxicity, with impaired renal function reducing clearance of both agents.
Conduite à tenir
Monitor serum creatinine and urine output, and consider kanamycin levels and hearing or vestibular symptoms during therapy. Adjust doses to renal function and keep the patient well hydrated.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Cefixime
- Cefixime + Typhoid vaccine live Majeure
- Cefixime + Cholera vaccine Modérée
- Cefixime + Microbiota Modérée
- Cefixime + Plazomicin Modérée
- Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Modérée
- Cefixime + Warfarin Modérée
Questions fréquentes
Can I take Cefixime with Kanamycin?
MediHelp rates the interaction as moderate. Cefixime and Kanamycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides such as kanamycin are nephrotoxic and ototoxic, and cephalosporins have occasionally been associated with additive renal injury when given alongside them. Cefixime is itself rarely nephrotoxic and is renally cleared, so reduced renal function may raise exposure to both drugs.
How serious is the interaction between Cefixime and Kanamycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output, and consider kanamycin levels and hearing or vestibular symptoms during therapy. Adjust doses to renal function and keep the patient well hydrated.
What other medicines interact with Cefixime?
MediHelp also lists interactions of Cefixime with, for example, Typhoid vaccine live, Cholera vaccine, Microbiota. The full list is on the Cefixime page.
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