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Interactions médicamenteuses

Cefixime + Plazomicin

Gravité: Modérée

Cefixime and Plazomicin: moderate interaction.

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Résumé

Plazomicin carries a boxed warning for nephrotoxicity, ototoxicity and neuromuscular blockade. Cefixime is renally cleared and may add to renal burden or accumulate if kidney function declines during plazomicin therapy.

Ce que signifie cette interaction, en termes simples

Cefixime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cefixime belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.

Niveau de preuve: Low

Pourquoi elle survient

Possible additive nephrotoxicity, with reduced renal clearance of both drugs if kidney function falls.

Conduite à tenir

Monitor serum creatinine before and during treatment, and adjust cefixime dosing if creatinine clearance falls. Use plazomicin therapeutic drug monitoring and watch for hearing or balance changes.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cefixime with Plazomicin?

MediHelp rates the interaction as moderate. Cefixime and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Plazomicin carries a boxed warning for nephrotoxicity, ototoxicity and neuromuscular blockade. Cefixime is renally cleared and may add to renal burden or accumulate if kidney function declines during plazomicin therapy.

How serious is the interaction between Cefixime and Plazomicin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine before and during treatment, and adjust cefixime dosing if creatinine clearance falls. Use plazomicin therapeutic drug monitoring and watch for hearing or balance changes.

What other medicines interact with Cefixime?

MediHelp also lists interactions of Cefixime with, for example, Typhoid vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefixime page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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