Interactions médicamenteuses
Cyclosporin + Elagolix
Gravité: Contre-indiquée
Cyclosporin and Elagolix: contraindicated interaction.
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Résumé
Cyclosporine inhibits OATP1B1 and substantially increases elagolix exposure, raising the risk of adverse effects such as bone loss, liver enzyme elevation and mood changes. Elagolix labeling prohibits use with strong OATP1B1 inhibitors such as cyclosporine.
Ce que signifie cette interaction, en termes simples
Cyclosporin and Elagolix are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Cyclosporin belongs to Miscellaneous; Elagolix belongs to Musculoskeletal.
Pourquoi elle survient
Cyclosporine inhibits OATP1B1-mediated hepatic uptake of elagolix, increasing its plasma concentration.
Conduite à tenir
Do not coadminister; choose alternative endometriosis therapy while cyclosporine is needed.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contre-indiquée
- Aliskiren + Cyclosporin Contre-indiquée
- Bcg vaccine live + Cyclosporin Contre-indiquée
- Bosentan + Cyclosporin Contre-indiquée
- Cidofovir + Cyclosporin Contre-indiquée
- Cyclosporin + Dengue vaccine Contre-indiquée
Autres interactions de Elagolix
- Elagolix + Gemfibrozil Contre-indiquée
- Desogestrel-ethinyl estradiol + Elagolix Majeure
- Elagolix + Erythromycin Majeure
- Elagolix + Ethinyl estradiol-drospirenone Majeure
- Elagolix + Ethinyl estradiol-levonorgestrel Majeure
- Elagolix + Ketoconazole Majeure
Questions fréquentes
Can I take Cyclosporin with Elagolix?
MediHelp rates the interaction as contraindicated. Cyclosporin and Elagolix are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Cyclosporine inhibits OATP1B1 and substantially increases elagolix exposure, raising the risk of adverse effects such as bone loss, liver enzyme elevation and mood changes. Elagolix labeling prohibits use with strong OATP1B1 inhibitors such as cyclosporine.
How serious is the interaction between Cyclosporin and Elagolix?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; choose alternative endometriosis therapy while cyclosporine is needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
