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Interactions médicamenteuses

Cidofovir + Vancomycin

Gravité: Majeure

Cidofovir and Vancomycin: major interaction.

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Résumé

Both drugs can injure the kidney, and combined use may raise the risk of acute kidney injury. Cidofovir carries a boxed warning for renal toxicity and its label advises against use with other nephrotoxic agents.

Ce que signifie cette interaction, en termes simples

Cidofovir and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cidofovir belongs to Anti Virals; Vancomycin belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive nephrotoxicity, with cidofovir causing proximal tubular injury and vancomycin contributing tubular toxicity.

Conduite à tenir

Avoid concurrent use where possible; if unavoidable, ensure hydration with probenecid per cidofovir protocol and monitor serum creatinine and urinalysis before each cidofovir dose. Consider alternatives to vancomycin.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cidofovir with Vancomycin?

MediHelp rates the interaction as major. Cidofovir and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can injure the kidney, and combined use may raise the risk of acute kidney injury. Cidofovir carries a boxed warning for renal toxicity and its label advises against use with other nephrotoxic agents.

How serious is the interaction between Cidofovir and Vancomycin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if unavoidable, ensure hydration with probenecid per cidofovir protocol and monitor serum creatinine and urinalysis before each cidofovir dose. Consider alternatives to vancomycin.

What other medicines interact with Vancomycin?

MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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