Interactions médicamenteuses
Colistin + Vancomycin
Gravité: Majeure
Colistin and Vancomycin: major interaction.
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Résumé
Both vancomycin and colistin are nephrotoxic, and combination therapy has been associated with a higher incidence of acute kidney injury than either drug alone. Colistin also carries neurotoxicity risk.
Ce que signifie cette interaction, en termes simples
Colistin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colistin belongs to Anti Bacterial; Vancomycin belongs to Anti Bacterial.
Pourquoi elle survient
Additive tubular nephrotoxicity from both drugs.
Conduite à tenir
Monitor serum creatinine and urine output daily and use vancomycin level-guided dosing. Consider alternatives to vancomycin if gram-positive coverage is not essential.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Vancomycin
- Amikacin + Vancomycin Majeure
- Bacitracin + Vancomycin Majeure
- Capreomycin + Vancomycin Majeure
- Cephaloridine + Vancomycin Majeure
- Cidofovir + Vancomycin Majeure
- Cisplatin + Vancomycin Majeure
Autres interactions de Colistin
- Colistin + Polymyxin b Contre-indiquée
- Amikacin + Colistin Majeure
- Amphotericin b deoxycholate + Colistin Majeure
- Amphotericin b + Colistin Majeure
- Atracurium + Colistin Majeure
- Bacitracin + Colistin Majeure
Questions fréquentes
Can I take Colistin with Vancomycin?
MediHelp rates the interaction as major. Colistin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both vancomycin and colistin are nephrotoxic, and combination therapy has been associated with a higher incidence of acute kidney injury than either drug alone. Colistin also carries neurotoxicity risk.
How serious is the interaction between Colistin and Vancomycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output daily and use vancomycin level-guided dosing. Consider alternatives to vancomycin if gram-positive coverage is not essential.
What other medicines interact with Vancomycin?
MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
