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Interactions médicamenteuses

Cisplatin + Vancomycin

Gravité: Majeure

Cisplatin and Vancomycin: major interaction.

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Résumé

Cisplatin is markedly nephrotoxic and ototoxic, and vancomycin adds further renal risk. The combination raises the likelihood of acute kidney injury, and reduced clearance may in turn increase vancomycin levels and cisplatin-related hearing loss.

Ce que signifie cette interaction, en termes simples

Cisplatin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cisplatin belongs to Oncology; Vancomycin belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive proximal tubular toxicity, with reduced renal clearance increasing exposure to both drugs.

Conduite à tenir

Use an alternative to vancomycin when possible. If necessary, monitor serum creatinine, magnesium and vancomycin levels closely, ensure hydration, and consider audiometry.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cisplatin with Vancomycin?

MediHelp rates the interaction as major. Cisplatin and Vancomycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cisplatin is markedly nephrotoxic and ototoxic, and vancomycin adds further renal risk. The combination raises the likelihood of acute kidney injury, and reduced clearance may in turn increase vancomycin levels and cisplatin-related hearing loss.

How serious is the interaction between Cisplatin and Vancomycin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use an alternative to vancomycin when possible. If necessary, monitor serum creatinine, magnesium and vancomycin levels closely, ensure hydration, and consider audiometry.

What other medicines interact with Vancomycin?

MediHelp also lists interactions of Vancomycin with, for example, Amikacin, Bacitracin, Capreomycin. The full list is on the Vancomycin page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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