Interactions médicamenteuses
Ciprofloxacin + Magnesium citrate
Gravité: Majeure
Ciprofloxacin and Magnesium citrate: major interaction.
Dernière mise à jour Sources: UK SmPC
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Résumé
Magnesium chelates ciprofloxacin in the gut and markedly reduces its absorption. This can cause subtherapeutic antibiotic levels and treatment failure.
Ce que signifie cette interaction, en termes simples
Ciprofloxacin and Magnesium citrate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ciprofloxacin belongs to Anti Bacterial; Magnesium citrate belongs to Gastrointestinal Tract.
Pourquoi elle survient
Chelation of ciprofloxacin by polyvalent magnesium cations in the gastrointestinal tract reduces absorption.
Conduite à tenir
Give oral ciprofloxacin at least 2 hours before or 6 hours after magnesium citrate. Avoid the combination if separation is impractical.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Références
- Ciprofloxacin 250mg film-coated tablets - SmPC sections 4.3/4.5 (class statement: multivalent cation-containing drugs and mineral supplements; "The simultaneous administration of ciprofloxacin (oral) and multivalent cation-containing drugs and mineral supplements (e.g. calcium, magnesium, aluminiu… — electronic medicines compendium (UK SmPC)
Autres interactions de Magnesium citrate
Autres interactions de Ciprofloxacin
- Agomelatine + Ciprofloxacin Contre-indiquée
- Ciprofloxacin + Fezolinetant Contre-indiquée
- Ciprofloxacin + Thioridazine Contre-indiquée
- Ciprofloxacin + Tizanidine Contre-indiquée
- Ciprofloxacin + Vandetanib Contre-indiquée
- Alosetron + Ciprofloxacin Majeure
Questions fréquentes
Can I take Ciprofloxacin with Magnesium citrate?
MediHelp rates the interaction as major. Ciprofloxacin and Magnesium citrate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Magnesium chelates ciprofloxacin in the gut and markedly reduces its absorption. This can cause subtherapeutic antibiotic levels and treatment failure.
How serious is the interaction between Ciprofloxacin and Magnesium citrate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give oral ciprofloxacin at least 2 hours before or 6 hours after magnesium citrate. Avoid the combination if separation is impractical.
What other medicines interact with Magnesium citrate?
MediHelp also lists interactions of Magnesium citrate with, for example, Baloxavir marboxil, Bictegravir, Cabotegravir. The full list is on the Magnesium citrate page.
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