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Interactions médicamenteuses

Cisplatin + Olaparib

Gravité: Majeure

Cisplatin and Olaparib: major interaction.

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Résumé

Olaparib combined with platinum agents increases the frequency and duration of myelosuppression, including anemia, neutropenia and thrombocytopenia. Dose modification or delays are often needed.

Ce que signifie cette interaction, en termes simples

Cisplatin and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cisplatin belongs to Oncology; Olaparib belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive myelosuppression; PARP inhibition impairs repair of platinum-induced DNA damage.

Conduite à tenir

Monitor complete blood counts regularly and interrupt or reduce doses for significant cytopenias, using established combination schedules.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cisplatin with Olaparib?

MediHelp rates the interaction as major. Cisplatin and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olaparib combined with platinum agents increases the frequency and duration of myelosuppression, including anemia, neutropenia and thrombocytopenia. Dose modification or delays are often needed.

How serious is the interaction between Cisplatin and Olaparib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly and interrupt or reduce doses for significant cytopenias, using established combination schedules.

What other medicines interact with Cisplatin?

MediHelp also lists interactions of Cisplatin with, for example, Cidofovir, Adefovir, Adenovirus types 4 and 7 live. The full list is on the Cisplatin page.

Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp

Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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