Interactions médicamenteuses
Clopidogrel + Esomeprazole
Gravité: Majeure
Clopidogrel and Esomeprazole: major interaction.
Dernière mise à jour Sources: US FDA label
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Esomeprazole reduces formation of clopidogrel's active metabolite and lowers its antiplatelet effect. This may increase the risk of thrombotic events, particularly in patients after stent placement or acute coronary syndrome. Labeling advises avoiding the combination.
Ce que signifie cette interaction, en termes simples
Clopidogrel and Esomeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clopidogrel belongs to Cardiovascular; Esomeprazole belongs to Gastrointestinal Tract.
Pourquoi elle survient
Esomeprazole inhibits CYP2C19, the enzyme needed to convert clopidogrel to its active thiol metabolite, reducing platelet P2Y12 inhibition.
Conduite à tenir
Avoid esomeprazole and omeprazole in patients taking clopidogrel. If gastroprotection is needed, use pantoprazole, which has weaker CYP2C19 inhibition, or an H2 antagonist other than cimetidine.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Clopidogrel et Esomeprazole, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Références
Autres interactions de Clopidogrel
- Clopidogrel + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contre-indiquée
- Abrocitinib + Clopidogrel Majeure
- Acetylsalicylic acid + Clopidogrel Majeure
- Apixaban + Clopidogrel Majeure
- Aspirin + Clopidogrel Majeure
- Betrixaban + Clopidogrel Majeure
Autres interactions de Esomeprazole
- Esomeprazole + Mavacamten Contre-indiquée
- Esomeprazole + Rilpivirine Contre-indiquée
- Acalabrutinib + Esomeprazole Majeure
- Atazanavir + Esomeprazole Majeure
- Citalopram + Esomeprazole Majeure
- Dacomitinib + Esomeprazole Majeure
Questions fréquentes
Can I take Clopidogrel with Esomeprazole?
MediHelp rates the interaction as major. Clopidogrel and Esomeprazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Esomeprazole reduces formation of clopidogrel's active metabolite and lowers its antiplatelet effect. This may increase the risk of thrombotic events, particularly in patients after stent placement or acute coronary syndrome. Labeling advises avoiding the combination.
How serious is the interaction between Clopidogrel and Esomeprazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid esomeprazole and omeprazole in patients taking clopidogrel. If gastroprotection is needed, use pantoprazole, which has weaker CYP2C19 inhibition, or an H2 antagonist other than cimetidine.
What other medicines interact with Clopidogrel?
MediHelp also lists interactions of Clopidogrel with, for example, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Abrocitinib, Acetylsalicylic acid. The full list is on the Clopidogrel page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
