Interactions médicamenteuses
Cobicistat + Irinotecan
Gravité: Majeure
Cobicistat and Irinotecan: major interaction.
Dernière mise à jour
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Résumé
Cobicistat inhibits CYP3A4, which converts irinotecan and its active metabolite SN-38 to inactive products. Exposure to toxic species may rise, increasing severe diarrhea and neutropenia.
Ce que signifie cette interaction, en termes simples
Cobicistat and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cobicistat belongs to Miscellaneous; Irinotecan belongs to Oncology.
Pourquoi elle survient
Cobicistat inhibits CYP3A4 (and transporters), reducing irinotecan oxidative clearance and increasing exposure to irinotecan and SN-38.
Conduite à tenir
Avoid the combination when possible and use a non-boosted antiretroviral regimen. If it cannot be avoided, monitor closely for diarrhea and neutropenia and consider irinotecan dose reduction.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Irinotecan
- Clozapine + Irinotecan Contre-indiquée
- Irinotecan + Sacituzumab govitecan Contre-indiquée
- Adenovirus types 4 and 7 live + Irinotecan Majeure
- Apalutamide + Irinotecan Majeure
- Atazanavir + Irinotecan Majeure
- Carbamazepine + Irinotecan Majeure
Autres interactions de Cobicistat
- Alfuzosin + Cobicistat Contre-indiquée
- Apalutamide + Cobicistat Contre-indiquée
- Cobicistat + Colchicine Contre-indiquée
- Cobicistat + Dronedarone Contre-indiquée
- Cobicistat + Eletriptan Contre-indiquée
- Cobicistat + Eplerenone Contre-indiquée
Questions fréquentes
Can I take Cobicistat with Irinotecan?
MediHelp rates the interaction as major. Cobicistat and Irinotecan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cobicistat inhibits CYP3A4, which converts irinotecan and its active metabolite SN-38 to inactive products. Exposure to toxic species may rise, increasing severe diarrhea and neutropenia.
How serious is the interaction between Cobicistat and Irinotecan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible and use a non-boosted antiretroviral regimen. If it cannot be avoided, monitor closely for diarrhea and neutropenia and consider irinotecan dose reduction.
What other medicines interact with Irinotecan?
MediHelp also lists interactions of Irinotecan with, for example, Clozapine, Sacituzumab govitecan, Adenovirus types 4 and 7 live. The full list is on the Irinotecan page.
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