Interactions médicamenteuses
Colesevelam + Cyclosporine
Gravité: Modérée
Colesevelam and Cyclosporine: moderate interaction.
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Résumé
Taken together, colesevelam lowers cyclosporine absorption, which could lead to subtherapeutic immunosuppression and risk of rejection. The effect is avoided when cyclosporine is taken well before colesevelam.
Ce que signifie cette interaction, en termes simples
Colesevelam and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Colesevelam binds cyclosporine in the gastrointestinal tract, reducing its absorption.
Conduite à tenir
Give cyclosporine at least 4 hours before colesevelam and monitor cyclosporine trough concentrations when starting or stopping colesevelam.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Modérée
- Amlodipine-olmesartan + Colesevelam Modérée
- Chenodiol + Colesevelam Modérée
- Cholic acid + Colesevelam Modérée
- Colesevelam + Cyclosporin Modérée
- Colesevelam + Gliclazide Modérée
Questions fréquentes
Can I take Colesevelam with Cyclosporine?
MediHelp rates the interaction as moderate. Colesevelam and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taken together, colesevelam lowers cyclosporine absorption, which could lead to subtherapeutic immunosuppression and risk of rejection. The effect is avoided when cyclosporine is taken well before colesevelam.
How serious is the interaction between Colesevelam and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give cyclosporine at least 4 hours before colesevelam and monitor cyclosporine trough concentrations when starting or stopping colesevelam.
What other medicines interact with Colesevelam?
MediHelp also lists interactions of Colesevelam with, for example, Amlodipine-olmesartan-hydrochlorothiazide, Amlodipine-olmesartan, Chenodiol. The full list is on the Colesevelam page.
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