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Interactions médicamenteuses

Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam

Gravité: Modérée

Amlodipine-olmesartan-hydrochlorothiazide and Colesevelam: moderate interaction.

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Résumé

Colesevelam can bind olmesartan in the gut and lower its absorption, possibly reducing blood pressure control. Binding of hydrochlorothiazide is also possible.

Ce que signifie cette interaction, en termes simples

Amlodipine-olmesartan-hydrochlorothiazide and Colesevelam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Colesevelam belongs to Endocrine.

Niveau de preuve: Moderate

Pourquoi elle survient

Bile acid sequestrant binds olmesartan in the gastrointestinal tract, reducing absorption.

Conduite à tenir

Give the combination tablet at least 4 hours before colesevelam. Monitor blood pressure if dosing cannot be separated.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Amlodipine-olmesartan-hydrochlorothiazide with Colesevelam?

MediHelp rates the interaction as moderate. Amlodipine-olmesartan-hydrochlorothiazide and Colesevelam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colesevelam can bind olmesartan in the gut and lower its absorption, possibly reducing blood pressure control. Binding of hydrochlorothiazide is also possible.

How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Colesevelam?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the combination tablet at least 4 hours before colesevelam. Monitor blood pressure if dosing cannot be separated.

What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?

MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.

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