Interactions médicamenteuses
Amlodipine-olmesartan + Colesevelam
Gravité: Modérée
Amlodipine-olmesartan and Colesevelam: moderate interaction.
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Résumé
Colesevelam binds olmesartan in the gut and reduces its absorption, which may weaken blood pressure control. The effect is greatest when both are taken at the same time.
Ce que signifie cette interaction, en termes simples
Amlodipine-olmesartan and Colesevelam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amlodipine-olmesartan belongs to Cardiovascular; Colesevelam belongs to Endocrine.
Pourquoi elle survient
Bile acid sequestrant binding of olmesartan in the gastrointestinal tract reduces its absorption.
Conduite à tenir
Give olmesartan at least 4 hours before colesevelam. Monitor blood pressure if dosing times cannot be separated.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Amlodipine-olmesartan
- Aliskiren + Amlodipine-olmesartan Contre-indiquée
- Amlodipine-olmesartan + Sparsentan Contre-indiquée
- Amifostine + Amlodipine-olmesartan Majeure
- Amiloride + Amlodipine-olmesartan Majeure
- Amlodipine-olmesartan + Benazepril Majeure
- Amlodipine-olmesartan + Captopril Majeure
Autres interactions de Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Modérée
- Chenodiol + Colesevelam Modérée
- Cholic acid + Colesevelam Modérée
- Colesevelam + Cyclosporin Modérée
- Colesevelam + Cyclosporine Modérée
- Colesevelam + Gliclazide Modérée
Questions fréquentes
Can I take Amlodipine-olmesartan with Colesevelam?
MediHelp rates the interaction as moderate. Amlodipine-olmesartan and Colesevelam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Colesevelam binds olmesartan in the gut and reduces its absorption, which may weaken blood pressure control. The effect is greatest when both are taken at the same time.
How serious is the interaction between Amlodipine-olmesartan and Colesevelam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give olmesartan at least 4 hours before colesevelam. Monitor blood pressure if dosing times cannot be separated.
What other medicines interact with Amlodipine-olmesartan?
MediHelp also lists interactions of Amlodipine-olmesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Amlodipine-olmesartan page.
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