Interactions médicamenteuses
Cholic acid + Colesevelam
Gravité: Modérée
Cholic acid and Colesevelam: moderate interaction.
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Résumé
Bile acid sequestrants bind bile acids in the gut and can reduce absorption of cholic acid, weakening its therapeutic effect in bile acid synthesis disorders.
Ce que signifie cette interaction, en termes simples
Cholic acid and Colesevelam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cholic acid belongs to Gastrointestinal Tract; Colesevelam belongs to Endocrine.
Pourquoi elle survient
Colesevelam binds cholic acid in the gastrointestinal lumen, reducing absorption.
Conduite à tenir
Take cholic acid at least 1 hour before or 4 to 6 hours after colesevelam, and monitor liver biochemistry and clinical response.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Modérée
- Amlodipine-olmesartan + Colesevelam Modérée
- Chenodiol + Colesevelam Modérée
- Colesevelam + Cyclosporin Modérée
- Colesevelam + Cyclosporine Modérée
- Colesevelam + Gliclazide Modérée
Autres interactions de Cholic acid
- Bosentan + Cholic acid Majeure
- Cholestyramine + Cholic acid Majeure
- Cholic acid + Glyburide Majeure
- Cholic acid + Glyburide-metformin Majeure
- Cholic acid + Ketoconazole Majeure
- Cholic acid + Mifepristone Majeure
Questions fréquentes
Can I take Cholic acid with Colesevelam?
MediHelp rates the interaction as moderate. Cholic acid and Colesevelam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bile acid sequestrants bind bile acids in the gut and can reduce absorption of cholic acid, weakening its therapeutic effect in bile acid synthesis disorders.
How serious is the interaction between Cholic acid and Colesevelam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take cholic acid at least 1 hour before or 4 to 6 hours after colesevelam, and monitor liver biochemistry and clinical response.
What other medicines interact with Colesevelam?
MediHelp also lists interactions of Colesevelam with, for example, Amlodipine-olmesartan-hydrochlorothiazide, Amlodipine-olmesartan, Chenodiol. The full list is on the Colesevelam page.
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