Interactions médicamenteuses
Chenodiol + Colesevelam
Gravité: Modérée
Chenodiol and Colesevelam: moderate interaction.
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Résumé
Bile acid sequestrants can bind chenodiol in the gut and reduce its absorption, and they also oppose its effect on bile acid pool. This may reduce gallstone dissolution or therapeutic effect.
Ce que signifie cette interaction, en termes simples
Chenodiol and Colesevelam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Chenodiol belongs to Gastrointestinal Tract; Colesevelam belongs to Endocrine.
Pourquoi elle survient
Resin binding of bile acids in the gut lowers absorption and enterohepatic availability of chenodiol.
Conduite à tenir
Avoid concurrent use if possible; if needed, separate doses by several hours and monitor treatment response.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Colesevelam
- Amlodipine-olmesartan-hydrochlorothiazide + Colesevelam Modérée
- Amlodipine-olmesartan + Colesevelam Modérée
- Cholic acid + Colesevelam Modérée
- Colesevelam + Cyclosporin Modérée
- Colesevelam + Cyclosporine Modérée
- Colesevelam + Gliclazide Modérée
Autres interactions de Chenodiol
- Aluminum hydroxide + Chenodiol Modérée
- Calcium carbonate + Chenodiol Modérée
- Calcium + Chenodiol Modérée
- Chenodiol + Cholestyramine Modérée
- Chenodiol + Colestipol Modérée
- Chenodiol + Warfarin Modérée
Questions fréquentes
Can I take Chenodiol with Colesevelam?
MediHelp rates the interaction as moderate. Chenodiol and Colesevelam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bile acid sequestrants can bind chenodiol in the gut and reduce its absorption, and they also oppose its effect on bile acid pool. This may reduce gallstone dissolution or therapeutic effect.
How serious is the interaction between Chenodiol and Colesevelam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible; if needed, separate doses by several hours and monitor treatment response.
What other medicines interact with Colesevelam?
MediHelp also lists interactions of Colesevelam with, for example, Amlodipine-olmesartan-hydrochlorothiazide, Amlodipine-olmesartan, Cholic acid. The full list is on the Colesevelam page.
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