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Interactions médicamenteuses

Cyclosporin + Darolutamide

Gravité: Modérée

Cyclosporin and Darolutamide: moderate interaction.

Dernière mise à jour

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Résumé

Cyclosporine inhibits both P-gp and CYP3A4, and darolutamide is a substrate of both, so darolutamide exposure may increase. This could heighten adverse effects such as fatigue and cardiac or hepatic events.

Ce que signifie cette interaction, en termes simples

Cyclosporin and Darolutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Cyclosporin belongs to Miscellaneous; Darolutamide belongs to Miscellaneous.

Niveau de preuve: Moderate

Pourquoi elle survient

Combined P-gp and CYP3A4 inhibition by cyclosporine increases darolutamide absorption and reduces clearance.

Conduite à tenir

Monitor for darolutamide adverse reactions and reduce the dose if they emerge. Consider an alternative immunosuppressant if feasible.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cyclosporin with Darolutamide?

MediHelp rates the interaction as moderate. Cyclosporin and Darolutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine inhibits both P-gp and CYP3A4, and darolutamide is a substrate of both, so darolutamide exposure may increase. This could heighten adverse effects such as fatigue and cardiac or hepatic events.

How serious is the interaction between Cyclosporin and Darolutamide?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for darolutamide adverse reactions and reduce the dose if they emerge. Consider an alternative immunosuppressant if feasible.

What other medicines interact with Cyclosporin?

MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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