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Interactions médicamenteuses

Cyclosporin + Fluvastatin

Gravité: Majeure

Cyclosporin and Fluvastatin: major interaction.

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Résumé

Cyclosporine raises fluvastatin exposure and increases the risk of myopathy and rhabdomyolysis. The effect is dose related.

Ce que signifie cette interaction, en termes simples

Cyclosporin and Fluvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cyclosporin belongs to Miscellaneous; Fluvastatin belongs to Cardiovascular.

Niveau de preuve: High

Pourquoi elle survient

Cyclosporine inhibits hepatic uptake (OATP1B1) and possibly CYP2C9-mediated clearance of fluvastatin, increasing systemic levels.

Conduite à tenir

Limit fluvastatin to 20 mg twice daily at most, or choose another lipid-lowering approach. Counsel patients to report unexplained muscle pain or weakness and check creatine kinase if symptoms occur.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cyclosporin with Fluvastatin?

MediHelp rates the interaction as major. Cyclosporin and Fluvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine raises fluvastatin exposure and increases the risk of myopathy and rhabdomyolysis. The effect is dose related.

How serious is the interaction between Cyclosporin and Fluvastatin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit fluvastatin to 20 mg twice daily at most, or choose another lipid-lowering approach. Counsel patients to report unexplained muscle pain or weakness and check creatine kinase if symptoms occur.

What other medicines interact with Cyclosporin?

MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.

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