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Interactions médicamenteuses

Fluvastatin + Gemfibrozil

Gravité: Majeure

Fluvastatin and Gemfibrozil: major interaction.

Dernière mise à jour

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Résumé

Gemfibrozil inhibits OATP1B1 and glucuronidation and fibrates also have intrinsic myotoxicity, which can raise statin exposure. Fluvastatin is mainly cleared by CYP2C9, so the pharmacokinetic rise is smaller than for other statins, but myopathy and rhabdomyolysis remain possible.

Ce que signifie cette interaction, en termes simples

Fluvastatin and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Fluvastatin belongs to Cardiovascular; Gemfibrozil belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive myotoxicity with possible OATP1B1 inhibition

Conduite à tenir

Avoid where possible; if both are needed use the lowest fluvastatin dose, and advise patients to report muscle pain or dark urine; check CK if symptomatic.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Fluvastatin with Gemfibrozil?

MediHelp rates the interaction as major. Fluvastatin and Gemfibrozil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemfibrozil inhibits OATP1B1 and glucuronidation and fibrates also have intrinsic myotoxicity, which can raise statin exposure. Fluvastatin is mainly cleared by CYP2C9, so the pharmacokinetic rise is smaller than for other statins, but myopathy and rhabdomyolysis remain possible.

How serious is the interaction between Fluvastatin and Gemfibrozil?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible; if both are needed use the lowest fluvastatin dose, and advise patients to report muscle pain or dark urine; check CK if symptomatic.

What other medicines interact with Fluvastatin?

MediHelp also lists interactions of Fluvastatin with, for example, Cyclosporine, Cyclosporin, Letermovir. The full list is on the Fluvastatin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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