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Interactions médicamenteuses

Cyclosporin + Letermovir

Gravité: Majeure

Cyclosporin and Letermovir: major interaction.

Dernière mise à jour

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Résumé

Letermovir raises cyclosporine concentrations through CYP3A inhibition, and cyclosporine increases letermovir exposure by inhibiting OATP1B1/3. The combination can cause cyclosporine toxicity and increased letermovir adverse effects.

Ce que signifie cette interaction, en termes simples

Cyclosporin and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Cyclosporin belongs to Miscellaneous; Letermovir belongs to Anti Virals.

Niveau de preuve: High

Pourquoi elle survient

Letermovir inhibits CYP3A and cyclosporine inhibits OATP1B1/3 transport of letermovir.

Conduite à tenir

Reduce letermovir to 240 mg daily when given with cyclosporine. Monitor cyclosporine levels frequently during therapy and after letermovir is stopped.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Cyclosporin with Letermovir?

MediHelp rates the interaction as major. Cyclosporin and Letermovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Letermovir raises cyclosporine concentrations through CYP3A inhibition, and cyclosporine increases letermovir exposure by inhibiting OATP1B1/3. The combination can cause cyclosporine toxicity and increased letermovir adverse effects.

How serious is the interaction between Cyclosporin and Letermovir?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce letermovir to 240 mg daily when given with cyclosporine. Monitor cyclosporine levels frequently during therapy and after letermovir is stopped.

What other medicines interact with Cyclosporin?

MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.

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