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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Dalteparin + Defibrotide

Gravité: Contre-indiquée

Dalteparin and Defibrotide: contraindicated interaction.

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Résumé

Defibrotide has profibrinolytic and antithrombotic activity, and combining it with a low molecular weight heparin adds to the risk of bleeding. Labeling for defibrotide contraindicates concurrent systemic antithrombotic or fibrinolytic therapy.

Ce que signifie cette interaction, en termes simples

Dalteparin and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Dalteparin belongs to Cardiovascular; Defibrotide belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive pharmacodynamic effects on hemostasis from anticoagulation plus enhanced fibrinolysis.

Conduite à tenir

Do not give together; hold dalteparin around defibrotide therapy and use an alternative plan. Routine maintenance or reopening of central venous lines is the usual exception.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dalteparin with Defibrotide?

MediHelp rates the interaction as contraindicated. Dalteparin and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide has profibrinolytic and antithrombotic activity, and combining it with a low molecular weight heparin adds to the risk of bleeding. Labeling for defibrotide contraindicates concurrent systemic antithrombotic or fibrinolytic therapy.

How serious is the interaction between Dalteparin and Defibrotide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give together; hold dalteparin around defibrotide therapy and use an alternative plan. Routine maintenance or reopening of central venous lines is the usual exception.

What other medicines interact with Dalteparin?

MediHelp also lists interactions of Dalteparin with, for example, Ketorolac, Mifepristone, Abciximab. The full list is on the Dalteparin page.

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