Interactions médicamenteuses
Defibrotide + Edoxaban
Gravité: Contre-indiquée
Defibrotide and Edoxaban: contraindicated interaction.
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Résumé
Defibrotide has profibrinolytic and antithrombotic activity and may add to the bleeding risk of anticoagulants such as edoxaban. Defibrotide labeling contraindicates concomitant systemic anticoagulants or fibrinolytics. Serious hemorrhage is the concern.
Ce que signifie cette interaction, en termes simples
Defibrotide and Edoxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Defibrotide belongs to Cardiovascular; Edoxaban belongs to Cardiovascular.
Pourquoi elle survient
Additive pharmacodynamic effects on hemostasis from factor Xa inhibition and defibrotide's profibrinolytic activity.
Conduite à tenir
Do not co-administer; hold edoxaban while defibrotide is being given. Resume anticoagulation only after defibrotide therapy is finished and bleeding risk has been reassessed.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Edoxaban
- Apixaban + Edoxaban Contre-indiquée
- Edoxaban + Ketorolac Contre-indiquée
- Abciximab + Edoxaban Majeure
- Acetylsalicylic acid + Edoxaban Majeure
- Argatroban + Edoxaban Majeure
- Aspirin rectal + Edoxaban Majeure
Autres interactions de Defibrotide
- Alteplase + Defibrotide Contre-indiquée
- Apixaban + Defibrotide Contre-indiquée
- Argatroban + Defibrotide Contre-indiquée
- Dabigatran etexilate + Defibrotide Contre-indiquée
- Dalteparin + Defibrotide Contre-indiquée
- Defibrotide + Enoxaparin Contre-indiquée
Questions fréquentes
Can I take Defibrotide with Edoxaban?
MediHelp rates the interaction as contraindicated. Defibrotide and Edoxaban are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide has profibrinolytic and antithrombotic activity and may add to the bleeding risk of anticoagulants such as edoxaban. Defibrotide labeling contraindicates concomitant systemic anticoagulants or fibrinolytics. Serious hemorrhage is the concern.
How serious is the interaction between Defibrotide and Edoxaban?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; hold edoxaban while defibrotide is being given. Resume anticoagulation only after defibrotide therapy is finished and bleeding risk has been reassessed.
What other medicines interact with Edoxaban?
MediHelp also lists interactions of Edoxaban with, for example, Apixaban, Ketorolac, Abciximab. The full list is on the Edoxaban page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
