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Interactions médicamenteuses

Argatroban + Defibrotide

Gravité: Contre-indiquée

Argatroban and Defibrotide: contraindicated interaction.

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Résumé

Defibrotide has profibrinolytic and antithrombotic activity and, combined with the direct thrombin inhibitor argatroban, may increase hemorrhage risk. Defibrotide labeling contraindicates concomitant systemic anticoagulant or fibrinolytic therapy.

Ce que signifie cette interaction, en termes simples

Argatroban and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Argatroban belongs to Cardiovascular; Defibrotide belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive antithrombotic and profibrinolytic effects increase bleeding tendency.

Conduite à tenir

Do not use together; hold argatroban during defibrotide therapy or choose an alternative, except for routine central line maintenance.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Argatroban with Defibrotide?

MediHelp rates the interaction as contraindicated. Argatroban and Defibrotide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Defibrotide has profibrinolytic and antithrombotic activity and, combined with the direct thrombin inhibitor argatroban, may increase hemorrhage risk. Defibrotide labeling contraindicates concomitant systemic anticoagulant or fibrinolytic therapy.

How serious is the interaction between Argatroban and Defibrotide?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together; hold argatroban during defibrotide therapy or choose an alternative, except for routine central line maintenance.

What other medicines interact with Argatroban?

MediHelp also lists interactions of Argatroban with, for example, Ketorolac, Mifepristone, Abciximab. The full list is on the Argatroban page.

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