Interactions médicamenteuses
Dapagliflozin + Glibenclamide
Gravité: Modérée
Dapagliflozin and Glibenclamide: moderate interaction.
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Résumé
Dapagliflozin lowers glucose without stimulating insulin release, but combined with glyburide it increases the likelihood of hypoglycemia. The prolonged action of glyburide makes any episodes potentially long-lasting.
Ce que signifie cette interaction, en termes simples
Dapagliflozin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Glibenclamide belongs to Endocrine.
Pourquoi elle survient
Additive pharmacodynamic glucose lowering from SGLT2-mediated urinary glucose excretion and sulfonylurea-driven insulin secretion.
Conduite à tenir
Consider a lower glyburide dose when dapagliflozin is started. Monitor blood glucose closely and educate the patient about hypoglycemia.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Glibenclamide
- Bosentan + Glibenclamide Contre-indiquée
- Cholic acid + Glibenclamide Majeure
- Ciprofloxacin + Glibenclamide Majeure
- Clarithromycin + Glibenclamide Majeure
- Fluconazole + Glibenclamide Majeure
- Glibenclamide + Insulin degludec-liraglutide Majeure
Autres interactions de Dapagliflozin
- Chlorpropamide + Dapagliflozin Modérée
- Dapagliflozin + Gliclazide Modérée
- Dapagliflozin + Glimepiride Modérée
- Dapagliflozin + Glimepiride-pioglitazone Modérée
- Dapagliflozin + Glipizide Modérée
- Dapagliflozin + Glipizide-metformin Modérée
Questions fréquentes
Can I take Dapagliflozin with Glibenclamide?
MediHelp rates the interaction as moderate. Dapagliflozin and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin lowers glucose without stimulating insulin release, but combined with glyburide it increases the likelihood of hypoglycemia. The prolonged action of glyburide makes any episodes potentially long-lasting.
How serious is the interaction between Dapagliflozin and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a lower glyburide dose when dapagliflozin is started. Monitor blood glucose closely and educate the patient about hypoglycemia.
What other medicines interact with Glibenclamide?
MediHelp also lists interactions of Glibenclamide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glibenclamide page.
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