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Interactions médicamenteuses

Dapagliflozin + Gliclazide

Gravité: Modérée

Dapagliflozin and Gliclazide: moderate interaction.

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Résumé

Dapagliflozin added to a sulfonylurea such as gliclazide increases the risk of hypoglycemia. The SGLT2 inhibitor lowers glucose without stimulating insulin, so the effects are additive.

Ce que signifie cette interaction, en termes simples

Dapagliflozin and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Dapagliflozin belongs to Endocrine; Gliclazide belongs to Endocrine.

Niveau de preuve: High

Pourquoi elle survient

Additive glucose lowering from sulfonylurea insulin secretion plus SGLT2-mediated urinary glucose excretion.

Conduite à tenir

Consider reducing the gliclazide dose when dapagliflozin is started and monitor blood glucose closely during initiation.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dapagliflozin with Gliclazide?

MediHelp rates the interaction as moderate. Dapagliflozin and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin added to a sulfonylurea such as gliclazide increases the risk of hypoglycemia. The SGLT2 inhibitor lowers glucose without stimulating insulin, so the effects are additive.

How serious is the interaction between Dapagliflozin and Gliclazide?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the gliclazide dose when dapagliflozin is started and monitor blood glucose closely during initiation.

What other medicines interact with Gliclazide?

MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.

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