Interactions médicamenteuses
Dapagliflozin + Glimepiride-pioglitazone
Gravité: Modérée
Dapagliflozin and Glimepiride-pioglitazone: moderate interaction.
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Résumé
Dapagliflozin added to a sulfonylurea such as glimepiride raises the risk of hypoglycemia. Pioglitazone contributes further glucose lowering.
Ce que signifie cette interaction, en termes simples
Dapagliflozin and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dapagliflozin belongs to Endocrine; Glimepiride-pioglitazone belongs to Endocrine.
Pourquoi elle survient
Additive glucose-lowering through insulin-independent urinary glucose excretion plus sulfonylurea-driven insulin secretion.
Conduite à tenir
Consider reducing the glimepiride dose when dapagliflozin is added and monitor blood glucose.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Glimepiride-pioglitazone
Autres interactions de Dapagliflozin
- Chlorpropamide + Dapagliflozin Modérée
- Dapagliflozin + Glibenclamide Modérée
- Dapagliflozin + Gliclazide Modérée
- Dapagliflozin + Glimepiride Modérée
- Dapagliflozin + Glipizide Modérée
- Dapagliflozin + Glipizide-metformin Modérée
Questions fréquentes
Can I take Dapagliflozin with Glimepiride-pioglitazone?
MediHelp rates the interaction as moderate. Dapagliflozin and Glimepiride-pioglitazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dapagliflozin added to a sulfonylurea such as glimepiride raises the risk of hypoglycemia. Pioglitazone contributes further glucose lowering.
How serious is the interaction between Dapagliflozin and Glimepiride-pioglitazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the glimepiride dose when dapagliflozin is added and monitor blood glucose.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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