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Interactions médicamenteuses

Darunavir + Red yeast rice

Gravité: Majeure

Darunavir and Red yeast rice: major interaction.

Dernière mise à jour

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Résumé

Red yeast rice contains monacolin K, identical to lovastatin, a sensitive CYP3A4 substrate. Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4, so monacolin K exposure may rise and cause myopathy or rhabdomyolysis.

Ce que signifie cette interaction, en termes simples

Darunavir and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Darunavir belongs to Anti Virals; Red yeast rice belongs to Gastrointestinal Tract.

Niveau de preuve: Moderate

Pourquoi elle survient

Boosted darunavir inhibits CYP3A4, reducing monacolin K metabolism.

Conduite à tenir

Avoid the combination and use a statin less dependent on CYP3A4 such as pravastatin or rosuvastatin. Advise patients to report unexplained muscle pain or weakness.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Darunavir with Red yeast rice?

MediHelp rates the interaction as major. Darunavir and Red yeast rice can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Red yeast rice contains monacolin K, identical to lovastatin, a sensitive CYP3A4 substrate. Darunavir, usually given with ritonavir or cobicistat, strongly inhibits CYP3A4, so monacolin K exposure may rise and cause myopathy or rhabdomyolysis.

How serious is the interaction between Darunavir and Red yeast rice?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a statin less dependent on CYP3A4 such as pravastatin or rosuvastatin. Advise patients to report unexplained muscle pain or weakness.

What other medicines interact with Red yeast rice?

MediHelp also lists interactions of Red yeast rice with, for example, Ritonavir, Saquinavir, Tipranavir. The full list is on the Red yeast rice page.

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