Interactions médicamenteuses
Deflazacort + Measles mumps and rubella vaccine live
Gravité: Contre-indiquée
Deflazacort and Measles mumps and rubella vaccine live: contraindicated interaction.
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Résumé
The live attenuated MMR viruses may replicate excessively in patients immunosuppressed by deflazacort, risking vaccine-strain disease. The immune response may also be reduced.
Ce que signifie cette interaction, en termes simples
Deflazacort and Measles mumps and rubella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Glucocorticoid immunosuppression impairs control of live attenuated viruses and reduces vaccine immunogenicity.
Conduite à tenir
Avoid during immunosuppressive corticosteroid therapy; give at least four weeks before starting steroids or after stopping for the interval in labeling. Check immunity and consider immunoglobulin after exposure.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contre-indiquée
- Bcg vaccine live + Deflazacort Contre-indiquée
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contre-indiquée
- Deflazacort + Measles mumps and rubella vaccine Contre-indiquée
- Deflazacort + Measles mumps rubella and varicella vaccine live Contre-indiquée
- Deflazacort + Measles vaccine Contre-indiquée
Questions fréquentes
Can I take Deflazacort with Measles mumps and rubella vaccine live?
MediHelp rates the interaction as contraindicated. Deflazacort and Measles mumps and rubella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The live attenuated MMR viruses may replicate excessively in patients immunosuppressed by deflazacort, risking vaccine-strain disease. The immune response may also be reduced.
How serious is the interaction between Deflazacort and Measles mumps and rubella vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during immunosuppressive corticosteroid therapy; give at least four weeks before starting steroids or after stopping for the interval in labeling. Check immunity and consider immunoglobulin after exposure.
What other medicines interact with Deflazacort?
MediHelp also lists interactions of Deflazacort with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Deflazacort page.
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