Interactions médicamenteuses
Dexamethasone-neomycin-polymyxin + Lapatinib
Gravité: Majeure
Dexamethasone-neomycin-polymyxin and Lapatinib: major interaction.
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Résumé
Dexamethasone induces CYP3A4 and may substantially reduce lapatinib exposure, risking loss of efficacy. Lapatinib may modestly raise dexamethasone exposure through CYP3A4 and P-glycoprotein inhibition.
Ce que signifie cette interaction, en termes simples
Dexamethasone-neomycin-polymyxin and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Lapatinib belongs to Oncology.
Pourquoi elle survient
Dexamethasone induces CYP3A4 and increases lapatinib clearance, while lapatinib weakly inhibits CYP3A4 and P-glycoprotein.
Conduite à tenir
Avoid prolonged systemic dexamethasone with lapatinib where possible, or consider a lapatinib dose increase per labeling for strong inducers. Monitor tumor response and corticosteroid effects.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Majeure
- Dexamethasone-neomycin-polymyxin + Levofloxacin Majeure
- Dexamethasone-neomycin-polymyxin + Mifepristone Majeure
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Majeure
- Aldesleukin + Dexamethasone-neomycin-polymyxin Modérée
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Dexamethasone-neomycin-polymyxin Modérée
Autres interactions de Lapatinib
- Dofetilide + Lapatinib Contre-indiquée
- Ibutilide + Lapatinib Contre-indiquée
- Lapatinib + Pimozide Contre-indiquée
- Lapatinib + Saquinavir Contre-indiquée
- Lapatinib + Thioridazine Contre-indiquée
- Adagrasib + Lapatinib Majeure
Questions fréquentes
Can I take Dexamethasone-neomycin-polymyxin with Lapatinib?
MediHelp rates the interaction as major. Dexamethasone-neomycin-polymyxin and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dexamethasone induces CYP3A4 and may substantially reduce lapatinib exposure, risking loss of efficacy. Lapatinib may modestly raise dexamethasone exposure through CYP3A4 and P-glycoprotein inhibition.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Lapatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged systemic dexamethasone with lapatinib where possible, or consider a lapatinib dose increase per labeling for strong inducers. Monitor tumor response and corticosteroid effects.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Levofloxacin, Mifepristone. The full list is on the Dexamethasone-neomycin-polymyxin page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
