Interactions médicamenteuses
Dexamethasone-neomycin-polymyxin + Levofloxacin
Gravité: Majeure
Dexamethasone-neomycin-polymyxin and Levofloxacin: major interaction.
Dernière mise à jour
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Résumé
Fluoroquinolones and systemic corticosteroids together increase the risk of tendinitis and tendon rupture, particularly the Achilles tendon. Risk is higher in older patients and those on prolonged therapy.
Ce que signifie cette interaction, en termes simples
Dexamethasone-neomycin-polymyxin and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Levofloxacin belongs to Anti Bacterial.
Pourquoi elle survient
Additive tendon toxicity from fluoroquinolone effects on tenocytes and corticosteroid-impaired collagen turnover.
Conduite à tenir
Avoid the combination in older patients where alternatives exist. Stop levofloxacin at the first sign of tendon pain or inflammation and rest the limb.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Autres interactions de Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Majeure
- Dexamethasone-neomycin-polymyxin + Lapatinib Majeure
- Dexamethasone-neomycin-polymyxin + Mifepristone Majeure
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Majeure
- Aldesleukin + Dexamethasone-neomycin-polymyxin Modérée
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Dexamethasone-neomycin-polymyxin Modérée
Autres interactions de Levofloxacin
- Dronedarone + Levofloxacin Contre-indiquée
- Ibutilide + Levofloxacin Contre-indiquée
- Levofloxacin + Thioridazine Contre-indiquée
- Levofloxacin + Vandetanib Contre-indiquée
- Levofloxacin + Ziprasidone Contre-indiquée
- Adagrasib + Levofloxacin Majeure
Questions fréquentes
Can I take Dexamethasone-neomycin-polymyxin with Levofloxacin?
MediHelp rates the interaction as major. Dexamethasone-neomycin-polymyxin and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fluoroquinolones and systemic corticosteroids together increase the risk of tendinitis and tendon rupture, particularly the Achilles tendon. Risk is higher in older patients and those on prolonged therapy.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Levofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in older patients where alternatives exist. Stop levofloxacin at the first sign of tendon pain or inflammation and rest the limb.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Mifepristone. The full list is on the Dexamethasone-neomycin-polymyxin page.
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