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Interactions médicamenteuses

Dexamethasone-neomycin-polymyxin + Ketorolac

Gravité: Majeure

Dexamethasone-neomycin-polymyxin and Ketorolac: major interaction.

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Résumé

Ketorolac carries a high intrinsic risk of GI ulceration and bleeding, and corticosteroids add to this risk. The combination is of concern with systemic exposure to dexamethasone.

Ce que signifie cette interaction, en termes simples

Dexamethasone-neomycin-polymyxin and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Ketorolac belongs to Musculoskeletal.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive gastrointestinal mucosal injury from corticosteroids and potent NSAID prostaglandin inhibition.

Conduite à tenir

Keep ketorolac to the shortest course allowed by labeling and consider gastroprotection with a proton pump inhibitor. Avoid in patients with prior ulcer or GI bleed.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Dexamethasone-neomycin-polymyxin with Ketorolac?

MediHelp rates the interaction as major. Dexamethasone-neomycin-polymyxin and Ketorolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketorolac carries a high intrinsic risk of GI ulceration and bleeding, and corticosteroids add to this risk. The combination is of concern with systemic exposure to dexamethasone.

How serious is the interaction between Dexamethasone-neomycin-polymyxin and Ketorolac?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep ketorolac to the shortest course allowed by labeling and consider gastroprotection with a proton pump inhibitor. Avoid in patients with prior ulcer or GI bleed.

What other medicines interact with Dexamethasone-neomycin-polymyxin?

MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Lapatinib, Levofloxacin, Mifepristone. The full list is on the Dexamethasone-neomycin-polymyxin page.

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