Interactions médicamenteuses
Dexamethasone-neomycin-polymyxin + Mifepristone
Gravité: Majeure
Dexamethasone-neomycin-polymyxin and Mifepristone: major interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
Mifepristone is a glucocorticoid receptor antagonist and CYP3A4 inhibitor, so it can reduce dexamethasone effect at the receptor while raising its levels. Mifepristone's label advises that corticosteroid treatment may be less effective. This is most relevant for systemic dexamethasone.
Ce que signifie cette interaction, en termes simples
Dexamethasone-neomycin-polymyxin and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dexamethasone-neomycin-polymyxin belongs to Anti Bacterial; Mifepristone belongs to Endocrine.
Pourquoi elle survient
Glucocorticoid receptor antagonism by mifepristone plus CYP3A4 inhibition of dexamethasone metabolism.
Conduite à tenir
With systemic dexamethasone, anticipate reduced response and higher steroid doses may be needed, with close monitoring. Avoid relying on corticosteroids in patients on chronic mifepristone, such as for Cushing syndrome.
Questions à poser à votre pharmacien
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Dexamethasone-neomycin-polymyxin et Mifepristone, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Autres interactions de Dexamethasone-neomycin-polymyxin
- Dexamethasone-neomycin-polymyxin + Ketorolac Majeure
- Dexamethasone-neomycin-polymyxin + Lapatinib Majeure
- Dexamethasone-neomycin-polymyxin + Levofloxacin Majeure
- Dexamethasone-neomycin-polymyxin + Moxifloxacin Majeure
- Aldesleukin + Dexamethasone-neomycin-polymyxin Modérée
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Dexamethasone-neomycin-polymyxin Modérée
Autres interactions de Mifepristone
- Apixaban + Mifepristone Contre-indiquée
- Argatroban + Mifepristone Contre-indiquée
- Cisapride + Mifepristone Contre-indiquée
- Cortisone + Mifepristone Contre-indiquée
- Cyclosporin + Mifepristone Contre-indiquée
- Dabigatran etexilate + Mifepristone Contre-indiquée
Questions fréquentes
Can I take Dexamethasone-neomycin-polymyxin with Mifepristone?
MediHelp rates the interaction as major. Dexamethasone-neomycin-polymyxin and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mifepristone is a glucocorticoid receptor antagonist and CYP3A4 inhibitor, so it can reduce dexamethasone effect at the receptor while raising its levels. Mifepristone's label advises that corticosteroid treatment may be less effective. This is most relevant for systemic dexamethasone.
How serious is the interaction between Dexamethasone-neomycin-polymyxin and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With systemic dexamethasone, anticipate reduced response and higher steroid doses may be needed, with close monitoring. Avoid relying on corticosteroids in patients on chronic mifepristone, such as for Cushing syndrome.
What other medicines interact with Dexamethasone-neomycin-polymyxin?
MediHelp also lists interactions of Dexamethasone-neomycin-polymyxin with, for example, Ketorolac, Lapatinib, Levofloxacin. The full list is on the Dexamethasone-neomycin-polymyxin page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
