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Interactions médicamenteuses

Dihydroergotamine + Phenylephrine

Gravité: Majeure

Dihydroergotamine and Phenylephrine: major interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Both drugs cause vasoconstriction, and together they can cause marked hypertension and peripheral or cerebral ischemia. The effect is most relevant with systemic phenylephrine.

Ce que signifie cette interaction, en termes simples

Dihydroergotamine and Phenylephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Dihydroergotamine belongs to Central Nervous System; Phenylephrine belongs to Respiratory.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive alpha-adrenergic and serotonergic vasoconstriction.

Conduite à tenir

Avoid systemic phenylephrine with dihydroergotamine. If unavoidable, monitor blood pressure and for signs of ischemia such as limb coldness or chest pain.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Dihydroergotamine with Phenylephrine?

MediHelp rates the interaction as major. Dihydroergotamine and Phenylephrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs cause vasoconstriction, and together they can cause marked hypertension and peripheral or cerebral ischemia. The effect is most relevant with systemic phenylephrine.

How serious is the interaction between Dihydroergotamine and Phenylephrine?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic phenylephrine with dihydroergotamine. If unavoidable, monitor blood pressure and for signs of ischemia such as limb coldness or chest pain.

What other medicines interact with Phenylephrine?

MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Phenylephrine page.

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