Interactions médicamenteuses
Isocarboxazid + Phenylephrine
Gravité: Contre-indiquée
Isocarboxazid and Phenylephrine: contraindicated interaction.
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Résumé
Isocarboxazid irreversibly inhibits monoamine oxidase, and phenylephrine is a direct alpha-1 agonist; with MAO inhibition pressor response is potentiated because MAO inhibition reduces catecholamine breakdown and sensitises tissues. Heart-rate and blood pressure rises, arrhythmia or a hypertensive crisis can result.
Ce que signifie cette interaction, en termes simples
Isocarboxazid and Phenylephrine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Isocarboxazid belongs to Central Nervous System; Phenylephrine belongs to Respiratory.
Pourquoi elle survient
MAO inhibition potentiating sympathomimetic/pressor activity
Conduite à tenir
Do not co-administer; wait at least 14 days after stopping the MAO inhibitor before using it.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Autres interactions de Phenylephrine
- Phenelzine + Phenylephrine Contre-indiquée
- Phenylephrine + Tranylcypromine Contre-indiquée
- Bromocriptine + Phenylephrine Majeure
- Cocaine + Phenylephrine Majeure
- Dihydroergotamine intranasal + Phenylephrine Majeure
- Dihydroergotamine + Phenylephrine Majeure
Autres interactions de Isocarboxazid
- 5-HTP + Isocarboxazid Contre-indiquée
- Amitriptyline + Isocarboxazid Contre-indiquée
- Amobarbital + Isocarboxazid Contre-indiquée
- Amoxapine + Isocarboxazid Contre-indiquée
- Apraclonidine + Isocarboxazid Contre-indiquée
- Atomoxetine + Isocarboxazid Contre-indiquée
Questions fréquentes
Can I take Isocarboxazid with Phenylephrine?
MediHelp rates the interaction as contraindicated. Isocarboxazid and Phenylephrine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Isocarboxazid irreversibly inhibits monoamine oxidase, and phenylephrine is a direct alpha-1 agonist; with MAO inhibition pressor response is potentiated because MAO inhibition reduces catecholamine breakdown and sensitises tissues. Heart-rate and blood pressure rises, arrhythmia or a hypertensive crisis can result.
How serious is the interaction between Isocarboxazid and Phenylephrine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; wait at least 14 days after stopping the MAO inhibitor before using it.
What other medicines interact with Phenylephrine?
MediHelp also lists interactions of Phenylephrine with, for example, Phenelzine, Tranylcypromine, Bromocriptine. The full list is on the Phenylephrine page.
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