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Interactions médicamenteuses

Phenylephrine + Tranylcypromine

Gravité: Contre-indiquée

Phenylephrine and Tranylcypromine: contraindicated interaction.

Dernière mise à jour Sources: US FDA label

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Résumé

Tranylcypromine is an irreversible MAO inhibitor, and sympathomimetics can precipitate a hypertensive crisis. This may cause severe headache, stroke or death.

Ce que signifie cette interaction, en termes simples

Phenylephrine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Phenylephrine belongs to Respiratory; Tranylcypromine belongs to Central Nervous System.

Niveau de preuve: High

Pourquoi elle survient

Inhibition of MAO enhances norepinephrine stores and the pressor response to phenylephrine.

Conduite à tenir

Do not combine; avoid systemic phenylephrine during and for two weeks after tranylcypromine. Choose non-sympathomimetic alternatives.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Références

Questions fréquentes

Can I take Phenylephrine with Tranylcypromine?

MediHelp rates the interaction as contraindicated. Phenylephrine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tranylcypromine is an irreversible MAO inhibitor, and sympathomimetics can precipitate a hypertensive crisis. This may cause severe headache, stroke or death.

How serious is the interaction between Phenylephrine and Tranylcypromine?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; avoid systemic phenylephrine during and for two weeks after tranylcypromine. Choose non-sympathomimetic alternatives.

What other medicines interact with Phenylephrine?

MediHelp also lists interactions of Phenylephrine with, for example, Isocarboxazid, Phenelzine, Bromocriptine. The full list is on the Phenylephrine page.

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