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Interactions médicamenteuses

Bupropion-naltrexone + Linezolid

Gravité: Contre-indiquée

Bupropion-naltrexone and Linezolid: contraindicated interaction.

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Résumé

Linezolid is a reversible nonselective MAO inhibitor, and bupropion is contraindicated with MAO inhibitors because of the risk of hypertensive reactions and neurotoxicity. Serotonergic or noradrenergic excess can occur.

Ce que signifie cette interaction, en termes simples

Bupropion-naltrexone and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Bupropion-naltrexone belongs to Miscellaneous; Linezolid belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

MAO inhibition by linezolid combined with bupropion's dopaminergic and noradrenergic reuptake inhibition causes catecholamine excess and possible serotonergic toxicity.

Conduite à tenir

Do not co-administer; use an alternative antibiotic. If linezolid is urgent, stop bupropion-naltrexone and monitor closely, and avoid restarting it until at least 24 hours after the last linezolid dose.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Bupropion-naltrexone with Linezolid?

MediHelp rates the interaction as contraindicated. Bupropion-naltrexone and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Linezolid is a reversible nonselective MAO inhibitor, and bupropion is contraindicated with MAO inhibitors because of the risk of hypertensive reactions and neurotoxicity. Serotonergic or noradrenergic excess can occur.

How serious is the interaction between Bupropion-naltrexone and Linezolid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; use an alternative antibiotic. If linezolid is urgent, stop bupropion-naltrexone and monitor closely, and avoid restarting it until at least 24 hours after the last linezolid dose.

What other medicines interact with Bupropion-naltrexone?

MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.

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