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Interactions médicamenteuses

Bupropion + Linezolid

Gravité: Contre-indiquée

Bupropion and Linezolid: contraindicated interaction.

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Résumé

Linezolid is a reversible non-selective MAO inhibitor. Bupropion is contraindicated with MAO inhibitors because of the risk of hypertensive reactions, and linezolid may also raise the risk of serotonin toxicity or neurotoxicity. The combination can cause severe adverse reactions.

Ce que signifie cette interaction, en termes simples

Bupropion and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Bupropion belongs to Central Nervous System; Linezolid belongs to Anti Bacterial.

Niveau de preuve: Moderate

Pourquoi elle survient

MAO inhibition by linezolid enhances noradrenergic and dopaminergic stimulation from bupropion, with possible serotonergic toxicity.

Conduite à tenir

Avoid; choose an alternative antibiotic. If linezolid is urgent, stop bupropion and monitor closely for hypertension and serotonin toxicity.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Bupropion with Linezolid?

MediHelp rates the interaction as contraindicated. Bupropion and Linezolid are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Linezolid is a reversible non-selective MAO inhibitor. Bupropion is contraindicated with MAO inhibitors because of the risk of hypertensive reactions, and linezolid may also raise the risk of serotonin toxicity or neurotoxicity. The combination can cause severe adverse reactions.

How serious is the interaction between Bupropion and Linezolid?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid; choose an alternative antibiotic. If linezolid is urgent, stop bupropion and monitor closely for hypertension and serotonin toxicity.

What other medicines interact with Bupropion?

MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Bupropion page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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