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Interactions médicamenteuses

Eluxadoline + Oxymorphone

Gravité: Majeure

Eluxadoline and Oxymorphone: major interaction.

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Résumé

Eluxadoline is used for diarrhea-predominant IBS and can cause constipation and pancreatitis-related complications. Opioids worsen constipation, raising the risk of serious constipation-related events.

Ce que signifie cette interaction, en termes simples

Eluxadoline and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Eluxadoline belongs to Gastrointestinal Tract; Oxymorphone belongs to Musculoskeletal.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive reduction in gastrointestinal motility via opioid receptor activity in the gut.

Conduite à tenir

Avoid the combination where feasible; if constipation develops, stop eluxadoline and manage it. Monitor bowel function.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Eluxadoline with Oxymorphone?

MediHelp rates the interaction as major. Eluxadoline and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eluxadoline is used for diarrhea-predominant IBS and can cause constipation and pancreatitis-related complications. Opioids worsen constipation, raising the risk of serious constipation-related events.

How serious is the interaction between Eluxadoline and Oxymorphone?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where feasible; if constipation develops, stop eluxadoline and manage it. Monitor bowel function.

What other medicines interact with Oxymorphone?

MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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