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Interactions médicamenteuses

Etoposide + Olaparib

Gravité: Majeure

Etoposide and Olaparib: major interaction.

Dernière mise à jour

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Résumé

Both drugs cause bone marrow suppression, so the combination can intensify and prolong cytopenias. Anemia, neutropenia and thrombocytopenia are of particular concern.

Ce que signifie cette interaction, en termes simples

Etoposide and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Etoposide belongs to Oncology; Olaparib belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive myelosuppression from topoisomerase II inhibition and PARP inhibition with impaired DNA repair.

Conduite à tenir

Monitor complete blood counts frequently and reduce doses or delay cycles as needed. Provide supportive care such as growth factors per guidelines.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Etoposide with Olaparib?

MediHelp rates the interaction as major. Etoposide and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs cause bone marrow suppression, so the combination can intensify and prolong cytopenias. Anemia, neutropenia and thrombocytopenia are of particular concern.

How serious is the interaction between Etoposide and Olaparib?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently and reduce doses or delay cycles as needed. Provide supportive care such as growth factors per guidelines.

What other medicines interact with Etoposide?

MediHelp also lists interactions of Etoposide with, for example, Adenovirus types 4 and 7 live, Pentostatin, Cyclosporine. The full list is on the Etoposide page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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