Interactions médicamenteuses
Folic acid + Phenobarbital
Gravité: Modérée
Folic acid and Phenobarbital: moderate interaction.
Dernière mise à jour
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Résumé
Folic acid may modestly reduce phenobarbital concentrations, and long-term phenobarbital use is associated with lower folate status. The combination can affect seizure control, so folate supplementation should be monitored in patients with epilepsy.
Ce que signifie cette interaction, en termes simples
Folic acid and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pourquoi elle survient
Phenobarbital induces hepatic enzymes and impairs folate status, while folate may increase anticonvulsant metabolism.
Conduite à tenir
Monitor seizure frequency and phenobarbital levels when starting or adjusting folic acid. Supplement folate where indicated at the lowest effective dose.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Folic acid
- Ethotoin + Folic acid Modérée
- Folic acid + Fosphenytoin Modérée
- Folic acid + Glucarpidase Modérée
- Folic acid + Methotrexate Modérée
- Folic acid + Pafolacianine Modérée
- Folic acid + Phenytoin Modérée
Questions fréquentes
Can I take Folic acid with Phenobarbital?
MediHelp rates the interaction as moderate. Folic acid and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Folic acid may modestly reduce phenobarbital concentrations, and long-term phenobarbital use is associated with lower folate status. The combination can affect seizure control, so folate supplementation should be monitored in patients with epilepsy.
How serious is the interaction between Folic acid and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor seizure frequency and phenobarbital levels when starting or adjusting folic acid. Supplement folate where indicated at the lowest effective dose.
What other medicines interact with Folic acid?
MediHelp also lists interactions of Folic acid with, for example, Ethotoin, Fosphenytoin, Glucarpidase. The full list is on the Folic acid page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
