Interactions médicamenteuses
Folic acid + Fosphenytoin
Gravité: Modérée
Folic acid and Fosphenytoin: moderate interaction.
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Résumé
Folic acid supplementation can lower phenytoin concentrations, which are the active form of fosphenytoin, and may lead to loss of seizure control. The effect is more likely with higher folate doses.
Ce que signifie cette interaction, en termes simples
Folic acid and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Folic acid belongs to Miscellaneous; Fosphenytoin belongs to Central Nervous System.
Pourquoi elle survient
Folate may increase phenytoin metabolism; the exact mechanism is not firmly established.
Conduite à tenir
Monitor phenytoin levels and seizure frequency when folic acid is started or changed. Adjust the fosphenytoin dose as needed.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Folic acid
- Ethotoin + Folic acid Modérée
- Folic acid + Glucarpidase Modérée
- Folic acid + Methotrexate Modérée
- Folic acid + Pafolacianine Modérée
- Folic acid + Phenobarbital Modérée
- Folic acid + Phenytoin Modérée
Autres interactions de Fosphenytoin
- Dronedarone + Fosphenytoin Contre-indiquée
- Fosphenytoin + Ledipasvir-sofosbuvir Contre-indiquée
- Fosphenytoin + Lorlatinib Contre-indiquée
- Fosphenytoin + Lurasidone Contre-indiquée
- Fosphenytoin + Ranolazine Contre-indiquée
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contre-indiquée
Questions fréquentes
Can I take Folic acid with Fosphenytoin?
MediHelp rates the interaction as moderate. Folic acid and Fosphenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Folic acid supplementation can lower phenytoin concentrations, which are the active form of fosphenytoin, and may lead to loss of seizure control. The effect is more likely with higher folate doses.
How serious is the interaction between Folic acid and Fosphenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin levels and seizure frequency when folic acid is started or changed. Adjust the fosphenytoin dose as needed.
What other medicines interact with Folic acid?
MediHelp also lists interactions of Folic acid with, for example, Ethotoin, Glucarpidase, Methotrexate. The full list is on the Folic acid page.
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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
