Interactions médicamenteuses
Folic acid + Phenytoin
Gravité: Modérée
Folic acid and Phenytoin: moderate interaction.
Dernière mise à jour
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Résumé
Folic acid, especially at high doses, can lower serum phenytoin levels and has been linked with reduced seizure control. Phenytoin can also lower folate levels, so supplementation is often needed.
Ce que signifie cette interaction, en termes simples
Folic acid and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Folic acid belongs to Miscellaneous; Phenytoin belongs to Central Nervous System.
Pourquoi elle survient
Folate may increase the hepatic metabolism of phenytoin, while phenytoin impairs folate absorption and status.
Conduite à tenir
Monitor phenytoin levels and seizure frequency when starting or adjusting folic acid. Adjust the phenytoin dose if levels fall.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Phenytoin
- Artemether / lumefantrine + Phenytoin Contre-indiquée
- Bictegravir + Phenytoin Contre-indiquée
- Cabotegravir + Phenytoin Contre-indiquée
- Doravirine + Phenytoin Contre-indiquée
- Elbasvir / grazoprevir + Phenytoin Contre-indiquée
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contre-indiquée
Autres interactions de Folic acid
- Ethotoin + Folic acid Modérée
- Folic acid + Fosphenytoin Modérée
- Folic acid + Glucarpidase Modérée
- Folic acid + Methotrexate Modérée
- Folic acid + Pafolacianine Modérée
- Folic acid + Phenobarbital Modérée
Questions fréquentes
Can I take Folic acid with Phenytoin?
MediHelp rates the interaction as moderate. Folic acid and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Folic acid, especially at high doses, can lower serum phenytoin levels and has been linked with reduced seizure control. Phenytoin can also lower folate levels, so supplementation is often needed.
How serious is the interaction between Folic acid and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin levels and seizure frequency when starting or adjusting folic acid. Adjust the phenytoin dose if levels fall.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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