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Interactions médicamenteuses

Foscarnet + Vandetanib

Gravité: Contre-indiquée

Foscarnet and Vandetanib: contraindicated interaction.

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Résumé

Vandetanib carries a boxed warning for QT prolongation, torsades de pointes and sudden death. Foscarnet adds QT liability and may cause electrolyte disturbances, making the combination particularly hazardous.

Ce que signifie cette interaction, en termes simples

Foscarnet and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Foscarnet belongs to Anti Virals; Vandetanib belongs to Oncology.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive QT prolongation, with foscarnet-induced hypocalcemia, hypomagnesemia or hypokalemia further increasing risk.

Conduite à tenir

Avoid the combination; choose an alternative antiviral or defer vandetanib while foscarnet is needed. If unavoidable, monitor ECG and electrolytes very frequently and correct abnormalities immediately.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Foscarnet with Vandetanib?

MediHelp rates the interaction as contraindicated. Foscarnet and Vandetanib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Vandetanib carries a boxed warning for QT prolongation, torsades de pointes and sudden death. Foscarnet adds QT liability and may cause electrolyte disturbances, making the combination particularly hazardous.

How serious is the interaction between Foscarnet and Vandetanib?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; choose an alternative antiviral or defer vandetanib while foscarnet is needed. If unavoidable, monitor ECG and electrolytes very frequently and correct abnormalities immediately.

What other medicines interact with Foscarnet?

MediHelp also lists interactions of Foscarnet with, for example, Cidofovir, Pimozide, Thioridazine. The full list is on the Foscarnet page.

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