Interactions médicamenteuses
Fosphenytoin + Pyrimethamine
Gravité: Modérée
Fosphenytoin and Pyrimethamine: moderate interaction.
Dernière mise à jour
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Résumé
Pyrimethamine is an antifolate and phenytoin (the active form of fosphenytoin) can also lower folate status. Together they may add to folate deficiency and haematological toxicity. Reports of reduced anticonvulsant effect are inconsistent.
Ce que signifie cette interaction, en termes simples
Fosphenytoin and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Fosphenytoin belongs to Central Nervous System; Pyrimethamine belongs to Anti Parasitic.
Pourquoi elle survient
Additive folate antagonism; pyrimethamine inhibits dihydrofolate reductase and phenytoin impairs folate handling, and phenytoin levels may also change through unclear mechanisms.
Conduite à tenir
Monitor complete blood counts and seizure control, and check phenytoin concentrations if control changes. Give folinic acid with pyrimethamine as usually recommended.
Questions à poser à votre pharmacien
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Autres interactions de Pyrimethamine
- Deferiprone + Pyrimethamine Majeure
- Eliglustat + Pyrimethamine Majeure
- Acalabrutinib + Pyrimethamine Modérée
- Brexpiprazole + Pyrimethamine Modérée
- Dapsone + Pyrimethamine Modérée
- Folic acid + Pyrimethamine Modérée
Autres interactions de Fosphenytoin
- Dronedarone + Fosphenytoin Contre-indiquée
- Fosphenytoin + Ledipasvir-sofosbuvir Contre-indiquée
- Fosphenytoin + Lorlatinib Contre-indiquée
- Fosphenytoin + Lurasidone Contre-indiquée
- Fosphenytoin + Ranolazine Contre-indiquée
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contre-indiquée
Questions fréquentes
Can I take Fosphenytoin with Pyrimethamine?
MediHelp rates the interaction as moderate. Fosphenytoin and Pyrimethamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pyrimethamine is an antifolate and phenytoin (the active form of fosphenytoin) can also lower folate status. Together they may add to folate deficiency and haematological toxicity. Reports of reduced anticonvulsant effect are inconsistent.
How serious is the interaction between Fosphenytoin and Pyrimethamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and seizure control, and check phenytoin concentrations if control changes. Give folinic acid with pyrimethamine as usually recommended.
What other medicines interact with Pyrimethamine?
MediHelp also lists interactions of Pyrimethamine with, for example, Deferiprone, Eliglustat, Acalabrutinib. The full list is on the Pyrimethamine page.
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