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MediHelp Référence médicamenteuse

Interactions médicamenteuses

Gemfibrozil + Pitavastatin

Gravité: Majeure

Gemfibrozil and Pitavastatin: major interaction.

Dernière mise à jour

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Résumé

Gemfibrozil inhibits OATP1B1 and glucuronidation, which can raise pitavastatin exposure, and fibrates themselves can cause myopathy. The risk of myopathy and rhabdomyolysis rises accordingly.

Ce que signifie cette interaction, en termes simples

Gemfibrozil and Pitavastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Gemfibrozil belongs to Cardiovascular; Pitavastatin belongs to Cardiovascular.

Niveau de preuve: Moderate

Pourquoi elle survient

OATP1B1 inhibition raising statin exposure plus additive myotoxicity

Conduite à tenir

Avoid the combination; if a fibrate is needed, use a different class or fenofibrate, and monitor for muscle symptoms.

Questions à poser à votre pharmacien

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Gemfibrozil with Pitavastatin?

MediHelp rates the interaction as major. Gemfibrozil and Pitavastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Gemfibrozil inhibits OATP1B1 and glucuronidation, which can raise pitavastatin exposure, and fibrates themselves can cause myopathy. The risk of myopathy and rhabdomyolysis rises accordingly.

How serious is the interaction between Gemfibrozil and Pitavastatin?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; if a fibrate is needed, use a different class or fenofibrate, and monitor for muscle symptoms.

What other medicines interact with Pitavastatin?

MediHelp also lists interactions of Pitavastatin with, for example, Cyclosporine, Cyclosporin, Erythromycin base. The full list is on the Pitavastatin page.

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Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.

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