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Interactions médicamenteuses

Gemifloxacin + Ziprasidone

Gravité: Contre-indiquée

Gemifloxacin and Ziprasidone: contraindicated interaction.

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Résumé

Ziprasidone is known for QT prolongation and is contraindicated with other drugs that prolong the QT interval. Adding gemifloxacin raises the risk of torsades de pointes and sudden cardiac death.

Ce que signifie cette interaction, en termes simples

Gemifloxacin and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Gemifloxacin belongs to Anti Bacterial; Ziprasidone belongs to Central Nervous System.

Niveau de preuve: Moderate

Pourquoi elle survient

Additive prolongation of cardiac repolarization via potassium channel blockade.

Conduite à tenir

Do not combine; select a non-QT-prolonging antibiotic. If an antipsychotic change is needed, choose one with lower QT liability.

Questions à poser à votre pharmacien

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Gemifloxacin with Ziprasidone?

MediHelp rates the interaction as contraindicated. Gemifloxacin and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ziprasidone is known for QT prolongation and is contraindicated with other drugs that prolong the QT interval. Adding gemifloxacin raises the risk of torsades de pointes and sudden cardiac death.

How serious is the interaction between Gemifloxacin and Ziprasidone?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; select a non-QT-prolonging antibiotic. If an antipsychotic change is needed, choose one with lower QT liability.

What other medicines interact with Gemifloxacin?

MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.

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