Drug interactions
Gemifloxacin + Ziprasidone
Severity: Contraindicated
Gemifloxacin and Ziprasidone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone is known for QT prolongation and is contraindicated with other drugs that prolong the QT interval. Adding gemifloxacin raises the risk of torsades de pointes and sudden cardiac death.
What this interaction means in plain words
Gemifloxacin and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Gemifloxacin belongs to Anti Bacterial; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization via potassium channel blockade.
What to do
Do not combine; select a non-QT-prolonging antibiotic. If an antipsychotic change is needed, choose one with lower QT liability.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Gemifloxacin with Ziprasidone?
MediHelp rates the interaction as contraindicated. Gemifloxacin and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ziprasidone is known for QT prolongation and is contraindicated with other drugs that prolong the QT interval. Adding gemifloxacin raises the risk of torsades de pointes and sudden cardiac death.
How serious is the interaction between Gemifloxacin and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; select a non-QT-prolonging antibiotic. If an antipsychotic change is needed, choose one with lower QT liability.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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