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Interactions médicamenteuses

Glycerol phenylbutyrate + Haloperidol

Gravité: Modérée

Glycerol phenylbutyrate and Haloperidol: moderate interaction.

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Résumé

Glycerol phenylbutyrate is used to lower ammonia in urea cycle disorders, and haloperidol has been reported to raise ammonia levels. This may reduce disease control and risk hyperammonemic episodes.

Ce que signifie cette interaction, en termes simples

Glycerol phenylbutyrate and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Glycerol phenylbutyrate belongs to Miscellaneous; Haloperidol belongs to Central Nervous System.

Niveau de preuve: Low

Pourquoi elle survient

Haloperidol may increase blood ammonia, opposing the nitrogen-scavenging effect of glycerol phenylbutyrate; the mechanism is not fully established.

Conduite à tenir

Monitor plasma ammonia closely when haloperidol is started or adjusted, and adjust the phenylbutyrate dose as indicated. Consider an alternative antipsychotic if ammonia control worsens.

Questions à poser à votre pharmacien

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Questions fréquentes

Can I take Glycerol phenylbutyrate with Haloperidol?

MediHelp rates the interaction as moderate. Glycerol phenylbutyrate and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glycerol phenylbutyrate is used to lower ammonia in urea cycle disorders, and haloperidol has been reported to raise ammonia levels. This may reduce disease control and risk hyperammonemic episodes.

How serious is the interaction between Glycerol phenylbutyrate and Haloperidol?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely when haloperidol is started or adjusted, and adjust the phenylbutyrate dose as indicated. Consider an alternative antipsychotic if ammonia control worsens.

What other medicines interact with Haloperidol?

MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.

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