Drug interactions
Influenza virus vaccine quadrivalent intranasal + Leflunomide
Severity: Contraindicated
Influenza virus vaccine quadrivalent intranasal and Leflunomide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intranasal influenza vaccine contains live attenuated virus, which may replicate more readily in a patient immunosuppressed by leflunomide. This could cause vaccine-strain infection and the response may be reduced.
What this interaction means in plain words
Influenza virus vaccine quadrivalent intranasal and Leflunomide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Impaired lymphocyte function reduces control of live attenuated virus replication.
What to do
Avoid the live intranasal vaccine; use an inactivated injectable influenza vaccine instead.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
- Alefacept + Leflunomide Major
Frequently asked questions
Can I take Influenza virus vaccine quadrivalent intranasal with Leflunomide?
MediHelp rates the interaction as contraindicated. Influenza virus vaccine quadrivalent intranasal and Leflunomide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The intranasal influenza vaccine contains live attenuated virus, which may replicate more readily in a patient immunosuppressed by leflunomide. This could cause vaccine-strain infection and the response may be reduced.
How serious is the interaction between Influenza virus vaccine quadrivalent intranasal and Leflunomide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live intranasal vaccine; use an inactivated injectable influenza vaccine instead.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Leflunomide page.
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