Interactions médicamenteuses
Influenza virus vaccine quadrivalent intranasal + Siponimod
Gravité: Contre-indiquée
Influenza virus vaccine quadrivalent intranasal and Siponimod: contraindicated interaction.
Dernière mise à jour
Réservé aux professionnels de santé — à titre de référence uniquement. Cette page est un bref résumé, pas un avis médical, et ne remplace ni la notice officielle ni le jugement clinique. Vérifiez toujours avant de prescrire ou de délivrer.
Le contenu clinique de cette page n'est disponible qu'en anglais.
Résumé
The intranasal influenza vaccine contains live attenuated virus, which could cause vaccine-strain infection in a patient with siponimod-induced lymphopenia. Immune suppression also makes the vaccine response unreliable. Live vaccines should not be given during siponimod therapy.
Ce que signifie cette interaction, en termes simples
Influenza virus vaccine quadrivalent intranasal and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pourquoi elle survient
Lymphocyte sequestration by S1P receptor modulation impairs control of live attenuated virus replication.
Conduite à tenir
Avoid live attenuated vaccines during siponimod and for about 4 weeks after discontinuation; use an inactivated influenza vaccine instead. If a live vaccine is needed, give it at least 4 weeks before starting siponimod.
Questions à poser à votre pharmacien
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Réservé aux membres Pro+
Débloquer la page complète
Créez un compte et lancez un essai Pro+ pour débloquer les conseils complets de prise en charge pour Influenza virus vaccine quadrivalent intranasal et Siponimod, les notes complémentaires, le détail des données probantes et le vérificateur d'interactions pour une ordonnance complète.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Essayez Pro+ gratuitement pendant 14 jours sur le web. Sans carte.
Autres interactions de Siponimod
- Cladribine + Siponimod Contre-indiquée
- Fingolimod + Siponimod Contre-indiquée
- Fluconazole + Siponimod Contre-indiquée
- Ponesimod + Siponimod Contre-indiquée
- Siponimod + Thioridazine Contre-indiquée
- Adenovirus types 4 and 7 live + Siponimod Majeure
Questions fréquentes
Can I take Influenza virus vaccine quadrivalent intranasal with Siponimod?
MediHelp rates the interaction as contraindicated. Influenza virus vaccine quadrivalent intranasal and Siponimod are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The intranasal influenza vaccine contains live attenuated virus, which could cause vaccine-strain infection in a patient with siponimod-induced lymphopenia. Immune suppression also makes the vaccine response unreliable. Live vaccines should not be given during siponimod therapy.
How serious is the interaction between Influenza virus vaccine quadrivalent intranasal and Siponimod?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live attenuated vaccines during siponimod and for about 4 weeks after discontinuation; use an inactivated influenza vaccine instead. If a live vaccine is needed, give it at least 4 weeks before starting siponimod.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
Monographies complètes, posologies et vérificateur d'interactions dans l'application MediHelp
Ouvrez le référentiel complet, vérifiez les interactions entre plusieurs médicaments et utilisez les outils de posologie dans l'application MediHelp.
